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| CEOLIN,PATRÍCIA; FRANÇA,SUÉLEM A. DE; FROELICH,MENDALLI; SANTOS,MAÍSA P. DOS; PEREIRA,MAYARA P.; QUEIROZ,THAÍS S.; SILVA,FLÁVIA H.S. DA; LISBOA,PATRÍCIA C.; ANDRADE,CLAUDIA M.B.; BAVIERA,AMANDA M.; KAWASHITA,NAIR H.. |
| Abstract: The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein, 74%-carbohydrate) for 45 days; C45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C45 group. The HOMA-IR index was similar between LPHC45 and C45 groups, but this parameter was lower in LPHC45 compared with R groups.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Low-protein; High-carbohydrate diet; Post-weaning period; HOMA-IR; Adiponectin. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300714 |
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| MAGALHÃES,DIEGO A. DE; KUME,WILLIAN T.; CORREIA,FRANCYELE S.; QUEIROZ,THAÍS S.; ALLEBRANDT NETO,EDGAR W.; SANTOS,MAÍSA P. DOS; KAWASHITA,NAIR H.; FRANÇA,SUÉLEM A. DE. |
| Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control group (commercial feed), and HF-STZ group, (66.5%-commercial feed, 13.5%-lard, and 20%-sugar). STZ (40mg/kg i.p.) or vehicle was administered on the 13th day. An oral glucose tolerance test (OGTT) was performed (2.5mg of glucose/kg v.o.) on both groups. After 39 days of treatment, blood and tissue samples were collected for analyses. The weight gain after STZ administration was lower in the HF-STZ group than in the control group with reductions in muscle mass and adipose tissue. The HF-STZ group showed hyperglycemia after STZ administration (glucose on day 39: HF-STZ: 499 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus type 2 model; High-fat diet; Streptozotocin; Rats. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100615 |
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